In vitro studies to understand inflammation in neuromyelitis optica spectrum disorder
2018
Medical University of Lodz, Lodz, Poland
Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system (CNS) inflammatory autoimmune illness leading to paralysis and blindness. Autoantibodies against astrocytes have been detected in the majority of NMOSD cases. In this study, the researchers aimed at understanding the mechanisms triggering inflammation, impairment of astrocyte function, and the role of neutrophils. They used a model based on in vitro culture of human astrocyte line and neutrophils isolated from healthy individuals supplemented with serum from NMOSD patients. The data showed the pathogenic capacity of the NMOSD serum, it also confirmed the role of autoantibodies and the interplay between astrocytes and neutrophils.
C5a-preactivated neutrophils are critical for autoimmune-induced astrocyte dysregulation in neuromyelitis optica spectrum disorder
Przemysław Lewkowicz
Added on: 10-28-2021
[1] https://www.frontiersin.org/articles/10.3389/fimmu.2018.01694/full[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
