Propofol modulates mammosphere formation of breast cancer cells
2019
Key Laboratory of Cancer Prevention and Therapy, Tianjin, China(1)
Tianjin Medical University Cancer Institute and Hospital, Tianjin, China(2)
Tianjin Medical University Cancer Institute and Hospital, Tianjin, China(2)
Recent studies have described that propofol can hinder cancer progression through the inhibition of cancer cell proliferation. Despite being a minor population in tumours, cancer stem cells have a crucial role in cancer progression and relapse after treatment. Here, human breast cancer cells were cultured in 2D and 3D to study in vitro the effects of propofol on breast cancer stem cells. The results show that propofol could reduce the ability of mammosphere formation and downregulates the expression of PD-L1 and Nanog. Furthermore, propofol had no effect on PD-L1 knockout breast cancer stem cells. Overall, the researchers demonstrate that propofol can inhibit mammosphere formation of breast cancer stem cells in vitro, potentially through the modulation of PD-L1.
Propofol reduced mammosphere formation of breast cancer stem cells via PD-L1/Nanog in vitro
Yue Yu(1), Hongwei Zhao(2)
Added on: 10-27-2021
[1] https://www.hindawi.com/journals/omcl/2019/9078209/[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
