Hyaluronan modulates breast cancer cell cycle
October 2018
Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Clinical evidence suggests that quiescent disseminated tumour cells can remain for a long time in the bone marrow influenced by the microenvironment. Hyaluronan is a major component of the bone marrow extracellular matrix and has been shown to regulate cancer cell and metastasis behaviour. Here, human breast cancer cells in 2D and 3D setups were used to test whether hyaluronan promotes breast cancer quiescence. The results showed that hyaluronan altered the cell cycle of metastatic cancer cells prolonging the G0/G1 phase through the modulation of ERK/p38 signalling pathways. Additionally, it was elucidated that there was an induction of p21cip1 expression together with a decrease in Cyclin D1 levels, which was confirmed in a 3D model together with low Ki-67 expression. Overall, the researchers verify that hyaluronan is a modulator of the cell cycle in 2D and 3D contexts and could contribute to cancer cell quiescence in the bone marrow.
Hyaluronan arrests human breast cancer cell growth by prolonging the G0/G1 phase of the cell cycle
Feng Gao
Added on: 10-27-2021
[1] https://academic.oup.com/abbs/article/50/12/1181/5146173[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
