Extracellular matrix regulates epigenetic changes in breast cancer
2016
China Medical University, Shenyang, China(1)
Washington State University Spokane, Spokane, USA(2)
Washington State University Spokane, Spokane, USA(2)
Different subtypes of breast cancer have different epigenetic signatures that can regulate gene expression and produce specific transcriptomic profiles. This differential epigenetic regulation can depend on the tumor microenvironment. In human patients, Claudin-low breast cancer is associated with triple-negative invasive ductal carcinomas. Here, a laminin rich extracellular matrix organotypic culture is used with human breast cancer cells to model Claudin-low breast cancer and explore the extracellular matrix-dependent epigenetic regulation of homeobox genes in cancer progression. The results showed that epigenetic changes induced the expression of certain homeobox genes and were dependent on interactions with the extracellular matrix through the binding of bromodomain-containing 4 to the HOXA9 promoter. In this study, the researchers demonstrate the importance of extracellular matrix-regulated epigenetic modulation of gene expression in a 3D human model of a subtype of breast cancer that can sustain the further development of new targets and therapeutical strategies.
Induction of HOXA9 expression in three-dimensional organotypic culture of the Claudin-low breast cancer cells
Miao Li(1), Bin Shan(2)
Added on: 10-25-2021
[1] https://www.oncotarget.com/article/10491/[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
