TBX3 promotes cancer progression
2016
Western University, London, Canada
The transcriptional regulator TBX3 has been described as a promoter of malignancy of tumour cells. More specifically, it was observed that it may promote cell survival and epithelial-to-mesenchymal transition. Here, TBX3 expression is modulated in three different cell lines of human breast cancer, representing distinct stages of cancer progression, to investigate the role of this factor in cancer-related features. The results showed that TBX3 is naturally more abundant in invasive breast cancer cells than in other cancer cell types. The overexpression of different isoforms of TBX3 resulted in the induction of cancerous behaviour in cells cultured in Matrigel in a 3D setup. Accordingly, when TBX3 was knocked down, there was a decrease in cancer-associated properties. Moreover, the transcriptomic analysis of cells with upregulated TBX3 corroborated the presence of alterations in cell survival, epithelial-to-mesenchymal transition, invasiveness and others. Overall, the researchers confirm that TBX3 is involved in several cell processes occurring during cancer progression and that it may be a key regulator of several cancer hallmarks.
The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer
Alan B Tuck
Added on: 10-20-2021
[1] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2697-z[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
