Human ex vivo skin model to check mechanisms of fibrosis in systemic sclerosis
2019
Medical University of South Carolina, Charleston, USA
Systemic sclerosis (SSc) is a multisystem connective tissue disease that has the highest disease-related mortality and morbidity among rheumatologic diseases and impairs quality of life. The pathophysiology is poorly understood, so there is an urgent need to develop good disease models. In the present study, researchers used ex vivo skin samples from plastic surgery remnants to elucidate the possible role of COL22A1, a gene involved in the extracellular matrix, in systemic sclerosis (SSc). The data suggest that COL22A1, as an early response gene that may have important effects on fibroblast activation, is associated with the pathogenesis of fibrosis in SSc. Thus, this model represents an important tool with direct relevance to human disease to enable the evaluation of potential therapies.
A human skin model recapitulates systemic sclerosis dermal fibrosis and identifies COL22A1 as a TGFβ early response gene that mediates fibroblast to myofibroblast transition
Carol Feghali-Bostwick
Added on: 10-19-2021
[1] https://www.mdpi.com/2073-4425/10/2/75/htm[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
