Human ex vivo skin model to dissect role of autoantibodies in skin disease
2014
University of Lübeck, Lübeck, Germany
Epidermolysis bullosa acquisita (EBA)is an autoimmune disease with severe and chronic skin blistering. Although IgG is well-known to be the predominant autoantibody isotype of EBA, there is not much evidence for the pathogenicity of IgA, which may appear as the only autoantibody isotype in some EBA patients. In the present study, the researchers generated chimeric IgA autoantibodies and tested their pathogenic potential on skin samples from donors. The data shows the generation of strong immune reactions and dermal-epidermal separation. The findings showed that IgA autoantibodies have a direct pathogenic potential and should encourage the development of diagnostic and therapeutic methods for IgA-mediated diseases.
Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo
Andreas Recke
Added on: 10-19-2021
[1] https://www.jimmunol.org/content/early/2014/07/13/jimmunol.1400160/tab-article-info[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
