Human ex vivo skin samples used for microspectroscopic studies in psoriasis
2015
Centre hospitalier universitaire de Québec, Québec, Canada
Psoriasis is a chronic dermatosis which affects approximately 3% both men and women worldwide whatever their age. The etiology of this autoimmune pathology modulated by genetic, immunologic, and environmental factors but ultimately still poorly understood. In the present study, the researchers aimed at understanding better lipid and protein organization of psoriasis patients as this is understanding is essential to develop therapeutic strategies. Interestingly, infrared and Raman microspetroscopic studies on skin samples from donors revelead disordered structures of lipids and proteins in psoriasis patient. However, the authors stress that the psoriasis samples came from deceased patients and the healthy samples from breast cancer surgery. In the future, the study should be repeated with using samples with more consistent and comparable origin. Still, the differences seen could indicate major problems at the molecular level in psoriasis skin.
Using infrared and Raman microspectroscopies to compare ex vivo involved psoriatic skin with normal human skin
Gaétan Laroche
Added on: 10-18-2021
[1] https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-20/issue-06/067004/Using-infrared-and-Raman-microspectroscopies-to-compare-ex-vivo-involved/10.1117/1.JBO.20.6.067004.full[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
