Biofabricated 3D matrix to model bone tissue
October 2016
The George Washington University, Washington, USA
Metastasis is a devastating step in cancer progression that leads to severe complications. Bone tissue is one of the first and most invaded tissues in breast cancer. Nowadays, the available in vitro models to study this pathological process are still poorly related to the in vivo conditions. Here, a bioprinted 3D biomimetic bone hydrogel-based matrix is used to culture human breast cancer cells and human fetal osteoblasts and bone marrow mesenchymal stem cells to investigate their interactions. It was possible to print hydrogel-based bone matrices with bone stromal encapsulated cells. The results show that the presence of bone cells enhanced the proliferation of human breast cancer cells and their levels of vascular endothelial growth factor, but the cancer cells had the contrary effect on bone cells proliferation and stemness. Overall, the researchers propose a new 3D bioprinted platform to study the effects of different cell types in bone tissue microenvironment, which could be a useful tool for human breast cancer research.
3D bioprinting a cell-laden bone matrix for breast cancer metastasis study
Lijie Grace Zhang
Added on: 10-15-2021
[1] https://pubs.acs.org/doi/10.1021/acsami.6b10673[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
