Biomarker identification for Alzheimer's disease
2015
Korea Basic Science Institute, Chungbuk, South Korea(1)
Université de Lille 1, Villeneuve-d’Ascq, France(2)
Université de Lille 1, Villeneuve-d’Ascq, France(2)
Alzheimer's disease is the most prevalent form of dementia and is characterized by progressive brain degeneration that leads to cognitive deficits and death. Despite the increasing knowledge available, the onset mechanisms and biomarkers of the pathology remain unclear. Here, hippocampal CA4 and dentate gyrus subfields from Alzheimer's patients were investigated with mass spectrometry-based proteomic analysis combined with label-free quantification to identify potential biomarkers. The results elucidated 113 potential markers with a 2-fold difference in protein levels in Alzheimer's patients compared to controls. Five of these proteins were identified and validated as putative Alzheimer's biomarkers. Moreover, five upstream signalling factors were identified from the 113 differentially regulated proteins. Altogether, the researchers provide new information about altered proteins in Alzheimer's disease that could potentially be used as biomarkers for the diagnosis of the disease and, also, open the door to new therapeutical targets.
Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease
Young Mok Park(1), Isabelle Fournier(2)
Added on: 10-01-2021
[1] https://www.nature.com/articles/srep11138[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
