Deep brain stimulation improves speech performance in a Parkinson context
2018
RWTH Aachen University, Aachen, Germany
Parkinson's disease is a neurodegenerative disorder that leads to motor deficits, including speech. Although currently there is no effective treatment to stop the disease, deep brain stimulation in the subthalamic nucleus and globus pallidus internus has been described as an effective therapy. Here, a neural model is developed to evaluate the effects in speech performance of different dopamine levels in the striatum and activity levels in the subthalamic nucleus and the globus pallidus internus through syllable repetition task simulation. The results show that a decrease of dopamine levels in the striatum leads to different degrees of syllable sequencing errors, as seen in Parkinson's disease, which could be counteracted by a reduction in the activity in the subthalamic nucleus or the globus pallidus internus. The model developed in this study relates the reduction in syllable sequencing errors to the inhibition of the subthalamic nucleus and globus pallidus internus, which may bring new insights into the mechanisms by which deep brain stimulation improves speech performance in Parkinson's patients.
Inhibiting basal ganglia regions reduces syllable sequencing errors in Parkinson's disease: a computer simulation study
Bernd J Kröger
Added on: 09-24-2021
[1] https://www.frontiersin.org/articles/10.3389/fncom.2018.00041[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
