Theoretical model of osciallations in Parkinson's disease
2018
Chinese Academy of Sciences, Shanghai, China
Parkinson's disease is one of the most prevalent neurodegenerative disorders that commonly affects aged individuals. It is characterized by a progressive loss of dopaminergic neurons without a known trigger that reduces the dopamine levels in the striatum. However, associated phenomena have been observed in patients, like changes in oscillatory activities in the basal ganglia. Some nuclei interactions have been proposed to explain this abnormal activity, but the responsible mechanisms are unclear. Here, a model of the corticothalamic-basal ganglia mean firing rate was developed to investigate the causative mechanisms of these symptoms. The results show that changes in the properties of different nuclei can induce Parkinson's disease oscillations and different frequency bands can be observed. Additionally, the mechanisms behind these oscillations are well explained by the model and the numerical simulation results. Overall, the researchers provide new insights on the potential mechanisms that influence Parkinson's oscillations using a newly developed model that may be further used as a unifying framework to study defects in oscillations in Parkinson's disease.
The oscillatory boundary conditions of different frequency bands in Parkinson’s disease
Bing Hu, Luonan Chen
Added on: 09-24-2021
[1] https://www.sciencedirect.com/science/article/abs/pii/S0022519318302248[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
