Computational model to study side effects of deep brain stimulation
2016
Indian Institute of Technology Madras, Chennai, India
The subthalamic nucleus has been described to have a central role in conflictive decision making. Furthermore, in Parkinson's disease patients with deep brain stimulation surgery in the subthalamic nucleus, it was observed that conflictive decision making was impaired leading to impulsive behaviour. Here, a 2D computational model of different components of the basal ganglia is used to decipher the mechanisms behind these adverse effects. This model was complemented with experimental data and used to compare the outcome of probabilistic learning tasks in different groups of untreated and treated Parkinson's patients and a group that underwent deep brain stimulation surgery in the subthalamic nucleus. The results showed that treated groups made impulsive (small reaction time) decisions which led to poor performance. Moreover, depending on the position of the electrode for the deep brain stimulation in the subthalamic nucleus, there was a decrease in neural activity. Finally, antidromic activation of the globus pallidus externa decreased reaction time in deep brain stimulation patients without altering learning abilities. Overall, this model allowed the researchers to elucidate the potential causes of conflictive decision making alterations in Parkinson patients with deep brain stimulation in the subthalamic nucleus that can be further studied in experimental setups.
Probing the Role of medication, DBS electrode position, and antidromic activation on impulsivity using a computational model of basal ganglia
V. Srinivasa Chakravarthy
Added on: 09-24-2021
[1] https://www.frontiersin.org/articles/10.3389/fnhum.2016.00450[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
