Immune response to induce pluripotent cells evaluated ex vivo in donor cells
2017
Keio University School of Medicine, Tokyo, Japan
Stem cells are a promising source of novel therapies. In this context, induced pluripotent stem cells (iPSC) derived from somatic cells are now attracting much attention in regenerative medicine. To achieve clinical use of iPSC, a cell bank with diverse tissue compatibility markers is necessary to provide cells to a diversity of patients with minimum rejection. In the present study, the researchers evaluated the significance of tissue compatibility matching in hiPSC differentiated to Neural Stem /Progenitor Cell using different in vitro assays based on the co-culture of cells. The results showed low immune response even when cells are not matched which would indicate that a cell bank may not be so crucial to ease clinical use. It is important to verify whether these in vitro results are reproducible in a clinical setting.
Evaluation of the immunogenicity of human iPS cell-derived neural stem/progenitor cells in vitro
Hideyuki Okano, Masaya Nakamura
Added on: 09-20-2021
[1] https://www.sciencedirect.com/science/article/pii/S1873506117300077?via%3Dihub[2] https://data.jrc.ec.europa.eu/dataset/c1c15110-2338-422e-a228-d3f8e19262c3
