Expression profiling and in silico modelling in patients to perdict tissue compatibility
December 2015
Virginia Commonwealth University, Richmond, USA
Stem cell transplantation from HLA-matched donors (HLA is one of the main genetic markers for tissue compatibility) delivers curative therapy to patients with hematologic malignancies, but at the cost of significant morbidity derived from graft-versus-host disease and the immunosuppression administered to control it. In the present study, the researchers used whole-exome sequencing combined with in silico peptide-binding evaluation to estimate potential alloreactivity, resulting in GVHD. The study was conducted on 34 donor-recipient pairs for stem cell transplantation who were HLA-matched. The methodology was shown to be able to provide a quantitative basis for refining donor selection and titration of immunosuppression after stem cell transplantation.
Dynamical system modeling to simulate donor T Cell response to whole exome sequencing-derived recipient peptides demonstrates different alloreactivity potential in HLA-matched and -mismatched donor–recipient pairs
Amir A. Toor
Added on: 09-19-2021
[1] https://www.sciencedirect.com/science/article/pii/S1083879115018601[2] https://data.jrc.ec.europa.eu/dataset/c1c15110-2338-422e-a228-d3f8e19262c3
