In silico analysis of sequences of prostate cancer marker
2014
University of Beira Interior, Covilha, Portugal
The six transmembrane epithelial antigen of the prostate 1 (STEAP1) is present almost exclusively in prostatic cells; although it was shown to be overexpressed in prostate cancer, its function is not clear. In the present study, the researchers conducted an extensive in silico analysis of STEAP1 and related gene STEAP1B, and evaluate the in vitro STEAP1 and STEAP1B expression in human prostate cell lines. In addition, the putative post-transcriptional and post-translational modifications are evaluated through STEAP1 mRNA and protein stability, supplemented by a post-translational in silico analysis. The data indicate that STEAP1B2 is overexpressed specifically in neoplastic cells, and post-translational modifications may be involved in the regulation of STEAP1 expression in prostate cells.
Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms
Cláudio J Maia
Added on: 09-18-2021
[1] https://www.genesandcancer.com/article/13/text/[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
