In silico analysis of colorectal cancer patients genetic variations
2018
German Cancer Research Center (DKFZ), Heidelberg, Germany
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression of genes NLRC5 and PD-L1 have been reported in CRC. In the present study, the researchers aimed at selecting potential regulatory variants in the NLRC5 and PD-L1 genes by using several online in silico tools and investigating their influence on CRC risk in a cohort of 1424 patients. The data suggests that not only a single genetic variant but also an interaction between two or more variants within genes involved in immune regulation may play important roles in the onset of CRC, providing therefore novel biological information, which could eventually improve CRC risk management but also immunotherapy in CRC.
Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer
Calogerina Catalano
Added on: 09-18-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192385[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
