Subset of immune cells shown to influence outcome of bladder cancer patients
2017
University of Birmingham, Birmingham, United Kingdom
Bladder cancer is the seventh most common cancer in Western society. To be able to design immunotherapy, the tumour immune microenvironment has to be better understood. In the present study, the researchers studied the tumors of 114 patients by immunocytochemistry used a panel of markers for innate and adaptive immune cells. A specific profile of immune cells was characterized. This subtype of immune cells was isolated from donors and co-cultured in vitro with cancer cells and confirmed to induce changes in function and gene expression profile. Finally, the researchers assessed the presence of these immune cells in patients and showed that an increased number of those cells was associated with improved survival, indicative of a novel mechanism for immunotherapy.
Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer
Richard T. Bryan
Added on: 09-18-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184841[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
