Combination of immunotherapy approaches tested on cancer cell lines
2016
Cancer Center Amsterdam, Amsterdam, Netherlands
Using the ability of Natural Killer (NK) cells to kill liquid tumors as a therapeutic strategy is deep in its development but is in its early phases for solid tumors. Epidermal Growth Factor Receptor (EGFR) activates important pathways which control cell proliferation, survival and motility. Accordingly, dysregulation of the EGFR signalling cascade can support tumor growth and EGFR expression levels are elevated in many cancers. In the present study, the researchers aimed at examining the efficacy of anti-EGFP antibody treatment in combination with other treatments. Immune cells, Natural Killers, were prepared from peripheral blood and activated and used in combination with anti-EGFR antibodies to test their cytotoxic activity against cancer cells in vitro. The studies demonstrated an enhancement of cytotoxicity of NK cells when used in combination with anti-EGFR antibody.
Combination of NK cells and cetuximab to enhance anti-tumor responses in RAS mutant metastatic colorectal cancer
Hans J. van der Vliet
Added on: 09-17-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157830[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
