MicroRNA identified as potential immunotherapy target from patients' tissues
October 2016
Dana-Farber Cancer Institute, Boston, USA
In colorectal cancer, the degree of infiltration of T lymphocytes has been associated with a favourable prognosis. MicroRNAs are small non-coding RNAs that epigenetically regulate diverse biological and pathologic processes, including immune response and tumor progression. The let-7 microRNA family has been shown to play an important role in host immunity. In the present study, the researchers examined let-7 miRNA expression in colorectal cancer tissues from two U.S.-nationwide prospective cohort studies. This analysis was correlated with imaging analysis of immune cell infiltration of the tumors. The study shows that a specific microRNA of the let-7 family is associated with suppressing antitumor immunity in colorectal cancer and suggests that it could be a potential target of immunotherapy.
MicroRNA let-7, T cells, and patient survival in colorectal cancer
Shuji Ogino, Zhi Rong Qian
Added on: 09-14-2021
[1] https://cancerimmunolres.aacrjournals.org/content/4/11/927[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
