Telomere's length may influence leukocyte inflammatory profile in Alzheimer's disease
2015
University of Milan, Milan, Italy
Alzheimer's disease is a multifactorial neurodegenerative disease that involves several cell types. Leukocytes are one of these cell types, and their telomere length has been related to the development of the disease. Here, Alzheimer's patients were recruited to investigate the influence of leukocyte telomere length on Alzheimer's progression. The mini mental state examination correlated with telomere length and slow-progression Alzheimer's patients showed shorter telomeres compared to healthy and fast-progression ones. Moreover, Interleukin 10 has been related to inflammatory alleviation, thus the researchers compared its production among peripheral blood mononuclear cells' stimulation with amyloid-beta. Slow-progression patients' cells were the only ones of the three groups to show significant differences. The results elucidate a new possible mechanism that can be interesting to understand leukocyte's telomeres contribution to the disease and the therapeutic possibilities that may arise from it.
Leukocyte telomere length in Alzheimer’s disease patients with a different rate of progression
Beatrice Arosio
Added on: 08-20-2021
[1] https://content.iospress.com/articles/journal-of-alzheimers-disease/jad142808[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
