Computational tools to study human Superoxide Dismutase 2
2013
Federal University of Rio de Janeiro State, Rio de Janeiro, Brazil
Polymorphisms of the superoxide dismutase 2 gene have been related to the development of neurological disorders. In this study, all the known human variants of this gene were analysed with different algorithms. With this analysis and with well-fitted structural theoretical models, it was possible to see that all mutations lead to the pathogenicity of the protein. In the end, all this data, together with a phylogenic analysis, were included in a freely accessible database that can be used by biologists and clinicians. This will allow to further explore the outcomes of the mutations of the superoxide dismutase 2 gene in pathological processes in humans.
Structural modeling and in silico analysis of human Superoxide Dismutase 2
Joelma Freire De Mesquita
Added on: 08-06-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065558[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
