Mathematical model of amyloid beta aggreagtion
2018
Southwest Research Institute, San Antonio, USA
Aggregation of amyloid-beta peptides into oligomers and insoluble fibrils is thought to be associated with the development of Alzheimer's disease. In this study, the researchers propose a discrete mathematical model for the aggregation of amyloid-beta into toxic oligomers using chemical kinetics and population dynamics. With this model, they were able to establish the conditions to make the system equilibrium unstable and to find a formula to prevent the aggregation of amyloid-beta peptides. This model can be a powerful tool for drug designers to target amyloid-beta aggregation in neurodegeneration.
A discrete mathematical model for the aggregation of β-Amyloid
Maher A Dayeh
Added on: 08-05-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196402[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
