3D multicellular microfluidic platform to model neurodegenerative diseases
2018
University of North Carolina at Charlotte, Charlotte, USA
Mechanisms of Alzheimer's disease pathology remain poorly understood. In this study, the researchers develop a 3D multicellular model that integrates human neuronal cells, astrocytes and microglia in a microfluidic platform. This system recapitulated the key hallmarks of the disease that involved the different cell types present in the model, allowing the study of intercellular interactions relevant for the pathophysiology of Alzheimer's disease. In conclusion, this new model can help to develop better human brain models for mechanistic studies of neurodegenerative diseases that involve neuro-glial interactions and improve drug discovery.
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease
Hansang Cho
Added on: 08-04-2021
[1] https://www.nature.com/articles/s41593-018-0175-4[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
