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Nanoparticles to detect and inhibit β-amyloid aggregation

2018
Universidad de Chile, Independencia, Chile(1)
Universidad Tecnológica Metropolitana, San Joaquín, Chile(2)
#Alzheimer, #amyloid beta, #cytotoxicity, #nanoparticle, #protein aggregation
A microfluidic system is used to generate magneto-plasmonic nanoparticles coupled with peptide D1, which selectively binds to β-amyloid peptides associated with Alzheimer's disease. Afterwards, these nanoparticles were treated to reduce cytotoxicity, as demonstrated by the high cell viability in cytotoxic assays performed on a human neuroblastoma cell line. Overall, these nanoparticles inhibit fibril formation and aggregation, thus they could be potential therapeutic and diagnostic tools for Alzheimer's disease.
Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation
M J Kogan(1), N Hassan(2)

N Hassan et al. Journal of Materials Chemistry B 2018 [1]   URL
EURL ECVAM [2]   URL
#787
Added on: 08-04-2021
[1] https://pubs.rsc.org/en/content/articlelanding/2018/TB/C8TB00206A[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
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