3D chip tumor model for high-throughput drug efficacy evaluation
2018
Tsinghua University, Shenzhen, China
A cancer-on-chip device with a vascular-like system and multicellular tumor spheroids was used to evaluate therapeutic nanoparticle-based drug delivery. The model allows for the evaluation of dynamic transport and cytotoxicity at the same time. In this model, it was possible to observe the differences in the efficacy of different therapeutic strategies in different human breast cancer subtypes, both at the level of penetrance and cytotoxicity. Overall, this model allows for high-throughput analysis of several aspects involved in drug efficacy in a 3D tumor microenvironment.
A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems
Dan Gao
Added on: 08-02-2021
[1] https://www.sciencedirect.com/science/article/abs/pii/S0003267018308031[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
