3D model to reproduce tumor physiology
November 2016
Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia
In this study, a 3D spheroid model is used combined with a HER2+ human breast adenocarcinoma cell line. This allows for better reproduction of the intercellular structures that avoid anti-cancer drug penetrance inside tumor structures. In this case, when using the immunotoxin 4D5scFv-PE40 in this model, the cytotoxicity was significantly lower than in monolayer 2D cultures, confirming that 3D structure properties play a key role in drug response. This model can be further used in drug testing to overcome the current limitations.
Spheroids of HER2-positive breast adenocarcinoma for studying anticancer immunotoxins in vitro
I V Balalaeva
Added on: 08-02-2021
[1] http://actanaturae.ru/2075-8251/article/view/10398/202[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
