CAR T-cells to target ERBB2 tumors
2017
Universiti Putra Malaysia, Serdang, Malaysia
The study describes the production of chimeric antigen receptor T-cells that target human epidermal growth factor receptor 2 overexpressing human breast tumors. When co-culturing these modified T-cells with a human breast cancer cell line, there was a significant increase in apoptosis compared to non-modified T-cells. This strategy can be a potential tool to use immunotherapy against human epidermal growth factor receptor 2 expressing tumors.
Human CD3+ T-cells with the anti-ERBB2 chimeric antigen receptor exhibit efficient targeting and induce apoptosis in ERBB2 overexpressing breast cancer cells
Pooi Ling Mok
Added on: 07-31-2021
[1] https://www.mdpi.com/1422-0067/18/9/1797[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
