Matrix stiffness for tissue-specific cancer stem cell growth
2015
University of South Carolina, Columbia, USA
In this study, tunable hydrogels were used to find the optimum matrix stiffness for tissue-specific cancer stem cells growth. Different human cancer cell lines were cultivated on different 3D scaffolds and it was found that cancer stem cells from different origins have different optimum matrix stiffness. Additionally, it was possible to investigate the associated gene expression to the optimum cancer stem cell conditions, showing that this model can be useful to study cancer stem cell microenviornments and dynamics.
Optimum 3D matrix stiffness for maintenance of cancer stem cells is dependent on tissue origin of cancer cells
Esmaiel Jabbari
Added on: 07-31-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132377[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
