Transcriptomic profile of metastasis biopsis during treatment
2015
Karolinska Institutet and University Hospital, Stockholm, Sweden
During a phase III clinical trial, a series of breast tumor samples were extracted from a group of volunteer patients. It was possible to obtain high-quality transcriptomic data from most of the patients. The monitoring of gene expression showed differences in the profiles of patients undergoing monotherapy versus those who were getting combined therapy and these correlated with what could be seen with conventional radiology assessments. This showed that transcriptomic profiling can be done in longitudinal studies and gave new insight into relevant biological processes related to the treatment.
Gene expression profiling of sequential metastatic biopsies for biomarker discovery in breast cancer
Theodoros Foukakis
Added on: 07-31-2021
[1] https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.molonc.2015.03.011[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
