Computational discovery of transcriptional regulators in cancer
2015
National Institute of Genomic Medicine, Mexico City, Mexico
Implementation of a series of algorithms to analyze gene regulatory networks and transcriptional regulators in the context of breast cancer is presented. By analyzing 880 microarrays of biopsy samples from primary breast cancer, it was possible to describe several master regulators involved in well-known hallmarks of cancer. Overall, this study shows that these techniques could be a potential tool to understand the first stages of cancer development.
Transcriptional master regulator analysis in breast cancer genetic networks
Enrique Hernández-Lemus
Added on: 07-31-2021
[1] https://www.sciencedirect.com/science/article/abs/pii/S1476927115301262[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38