Imaging approach to study cancer-activated fibroblasts
November 2014
Université Libre de Bruxelles, Brussels, Belgium
To study the activation of fibroblasts during cancerous processes, a multicellular model is used to combine different human breast cancer cell lines with human fibroblasts. By monitoring with infrared imaging, it was possible to see clear differences in the chemical composition of cancer-stimulated fibroblasts, and this was reproducible with stimulation of different breast cancer cell lines. Finally, these changes can be related to secreted factors. This study demonstrates the value of the use of infrared imaging techniques to study microenvironment of breast tumors.
A FTIR imaging characterization of fibroblasts stimulated by various breast cancer cell lines
Saroj Kumar, Erik Goormaghtigh
Added on: 07-30-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111137[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
