Tunable hydrogel-based extracellular matrix for 3D culture
2018
University of Birmingham, Birmingham, United Kingdom
To try to understand cell dynamics in tumor microenvironments, a tunable hydrogel-based 3D culture system to grow human cancer cell lines is developed. By controlling the mechanical properties of the hydrogels and incorporating different cell adhesion peptides, encapsulated cells show higher cell viability than in other models and participate in processes of extracellular matrix degradation to induce cell proliferation and cluster formation. This model can bring new possibilities to the study of cellular interactions and dynamics within the extracellular matrix.
Design of synthetic extracellular matrices for probing breast cancer cell growth using robust cyctocompatible nucleophilic thiol-yne addition chemistry
Andrew P Dove
Added on: 07-30-2021
[1] https://www.sciencedirect.com/science/article/abs/pii/S0142961218303107[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
