In vitro analysis of natural killer cells from colorectal cancer at the molecular and cellular level
2018
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy
In patients with solid malignancies, NK cells have compromised functions. In the present study, the researchers studied NK cells at a molecular and cellular level from blood and tissue samples of patients with colorectal cancer (CRC) and compared them to NK cells from controls and patients with nononcologic inflammatory bowel disease. CRC NK cells showed decreased expression of activation marker and impaired degranulation activity. Further, NK cells in CRC secreted pro-angiogenic factors and induce endothelial cell proliferation, migration, adhesion, and the formation of capillary-like structures in vitro.
Angiogenin and the MMP9–TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer
Douglas M. Noonan
Added on: 07-29-2021
[1] https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201701103R[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
