A multicellular system to explore metastasis
2018
University of Pittsburgh, Pittsburgh, USA
An ex-vivo model based on a 3D chip microphysiological system mixing human liver samples with human breast cancer cells is used to study spontaneous dormancy of breast cancer cells suggested to be responsible for metastatic processes. The researchers could reproduce this "dormant" behaviour in their model and induce a proliferative state after diverse activation signals. With this system, they could explore relevant features of this type of cells, showing that this model can be used for biomarker research.
A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures
Alan Wells
Added on: 07-29-2021
[1] https://www.sciencedirect.com/science/article/pii/S1535947620332692[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
