Generation and testing of a novel immunotoxin against cancer in human cancer cell lines
2015
Instituto Politécnico Nacional, Yautepec Morelos, Mexico
The human epidermal growth factor receptors (ErbB or Her) are a family of four signal transduction proteins with intracellular domains that have tyrosine kinase
activity. Amplification or overexpression of Her2 disrupts normal cell control mechanisms and gives rise to aggressive tumor cells. In the present study, the researchers constructed an immunotoxin specific for Her2 and its cytotoxicity of probed in vitro on established human cancer cell lines. The generated immunotoxin displayed high cytotoxic capacities and could be a therapeutic candidate against Her2+ cancer.
Cytotoxic effect of the immunotoxin constructed of the ribosome inactivating protein curcin and the monoclonal antibody against Her2 receptor on tumor cells
Alma Leticia Martínez-Ayala
Lidia Patricia Jaramillo-Quintero et al. Bioscience, Biotechnology, and Biochemistry 2015 [1]
EURL ECVAM [2]
Added on: 07-28-2021
[1] https://www.tandfonline.com/doi/full/10.1080/09168451.2015.1006572[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
