In vitro tests of prostate cancer patients immune cells to improve prognosis
October 2015
Umeå University, Umeå, Sweden
In colorectal cancer (CRC) and prostate cancer (PC) the immune response may have contrasting effects on patient prognosis. In CRC, increased infiltration of macrophages is strongly associated with an improved prognosis while the opposite is true in PC. In this study, the researchers evaluated the distribution and prognostic value of different sets of macrophages in a cohort of 234 PC patients. Results show a significantly different ratio in PC compared to CRC patients with a correlation with prognosis. Researchers further used an in vitro cell culture model of tumour-activated macrophages (TaMs). The results support the importance of a “good inflammatory response” in the prognosis of CRC patients and suggest that manipulations of the macrophage phenotype may be important in the development of new treatment strategies in PC and other cancers where immune infiltration is generally linked to poor prognosis.
Secreted factors from colorectal and prostate cancer cells skew the immune response in opposite directions
Sofia Edin
Added on: 07-28-2021
[1] https://www.nature.com/articles/srep15651[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
