Sensitive method to detect the presence of memory T cells in skin cancer patients
2019
National Institutes of Health, Bethesda, USA
T cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients and could potentially be used to develop personalized cancer immunotherapy. Unfortunately, detection of cells in the peripheral blood of patients with the common metastatic epithelial cancer patients is unknown. In the present study, the researchers used a highly sensitive in vitro stimulation and cell enrichment of peripheral memory T cells from six metastatic cancer patients. Memory T cells targeting unique, as well as shared somatic mutations, could be detected. The results should pave the way for developing personalized immunotherapy.
Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
Steven A. Rosenberg
Added on: 07-28-2021
[1] https://www.nature.com/articles/s41467-019-08304-z[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
