Method to generate immune killer cells against cancer from patients' blood
2016
Aichi Cancer Center Research Institute, Aichi, Japan(1)
Kyoto University, Kyoto, Japan(2)
Kyoto University, Kyoto, Japan(2)
A subset of T lymphocytes called invariant natural killer (iNKT) recognizes lipid antigens presented on antigen-presenting cells and induces both innate and adaptive immune responses against cancer. Reduced iNKT cell numbers and functions have been observed in many patients with cancer. In the present study, the researchers aimed at establishing a method to increase the population of iNKT. The researchers generated induced pluripotent stem cells (iPSCs) from peripheral blood of healthy donors and reprogrammed them into human iNKT cells. In vitro assays were then used to characterize these iNKT cells and show their cytotoxicity potential against human cancer cell lines. These cells are unlimited and offer potentially effective immunotherapy against cancer.
Cellular adjuvant properties, direct cytotoxicity of re-differentiated Va24 invariant NKT-like cells from human induced pluripotent stem cells
Yasushi Uemura(1), Shin Kaneko(2)
Added on: 07-27-2021
[1] https://www.sciencedirect.com/science/article/pii/S2213671116000229[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
