Immunoscore method improves prediction of colorectal cancer survival
2016
Pierre and Marie Curie University, Paris, France
Microsatellite instability in colorectal cancer predicts favourable outcomes although the mechanistic link is still unclear. In the present study, the researchers performed a comprehensive analysis of microsatellite-instable patients' tumors using Immunoscore, a scoring system based on the quantification of cytotoxic and memory T cells in the core of the tumor and in the tumor’s invasive margin. The researchers demonstrated the superiority of Immunoscore over microsatellite instability in predicting survival. Thus, the immune infiltration and Immunoscore should better define the prognosis of colorectal cancer patients and identify the ones at risk of tumor recurrence.
Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability
Jerome Galon
Added on: 07-27-2021
[1] https://www.cell.com/immunity/fulltext/S1074-7613(16)30064-4?[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
