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Cancer cell-induced matrix remodeling in 3D culture

2014
FOM Institute AMOLF, Amsterdam, Netherlands
#3D model, #breast cancer, #cancer cells, #cell migration, #extracellular matrix, #hydrogel, #metastasis
Development of a new assay to study cancer cell migration in a hydrogel-based 3D model is presented. In the presence of human breast cancer cells, there is a reorganisation of the fibres of the extracellular matrix done by "leader" cells, which subsets the matrix in different subregions. Afterwards, other cells following a more randomised migratory profile invade these subsetted regions. This platform supports the study of micromechanical propertiesof cell cancer migration.
Effects of migrating cell-induced matrix reorganization on 3D cancer cell migration
Nicholas Agung Kurniawan

Wei Sun et al. Cellular and Molecular Bioengineering 2014 [1]   URL
EURL ECVAM [2]   URL
#691
Added on: 07-27-2021
[1] https://link.springer.com/article/10.1007/s12195-014-0324-0[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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