Virtual screening method to discover tumor escape inhibitors
2017
Jilin University, Jilin, China(1)
Second Military Medical University, Shanghai, China(2)
Second Military Medical University, Shanghai, China(2)
Tumor escape is a hallmark of cancer, which brings many difficulties and troubles in cancer therapy. Indoleamine 2,3-dioxygenase 1 (IDO1) plays an important role in the immune escape of tumors, although it has emerged as a promising target for cancer therapy there are still very few drugs developed. In the present study, the researchers have designed a novel high throughput virtual screening to
search for potential IDO1 inhibitors. The screening method was used to screen commercially available compounds and identified some candidates with inhibition activity. Some of the compounds may serve as interesting starting points for future chemistry elaboration. The screening method was validated as a tool to be employed in the discovery of IDO1 inhibitors.
A novel high throughput virtual screening protocol to discover new indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Qing Yang(1), Yunlong Song(2)
Added on: 07-27-2021
[1] https://www.jstage.jst.go.jp/article/cpb/65/8/65_c16-01010/_article[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
