Mathematical model to improve local radiotherapy site decision
2016
H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA
For many years it has been speculated that localized radiotherapy for cancer metastases can occasionally generate a host immunotherapeutic response known as the abscopal effect. In the present study, the researchers describe a mathematical model that incorporates physiological information about immune cell trafficking through the patient circulatory system. The study shows that immune cell distribution varies significantly between different metastatic sites and depends on the immune system activation site. The presented framework could be used to inform about patient-specific treatment targets in metastatic patients.
The ability to purposefully and reliably induce abscopal effects in metastatic tumors could meet many unmet clinical needs.
Abscopal benefits of localized radiotherapy depend on activated T cell trafficking and distribution between metastatic lesions
Jan Poleszczuk
Added on: 07-26-2021
[1] https://cancerres.aacrjournals.org/content/early/2016/01/30/0008-5472.CAN-15-1423[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
