Computational assessment of tumor heterogeneity
2019
Stanford University School of Medicine, Stanford, USA
The computational model presented in this study allows assessing tumor heterogeneity and clonal replacement throughout treatment. It was used to study five human breast cancer tumors treated with HER2-targeted therapy. This model is able to show that two of these tumors underwent clonal replacement and that the resistant subclones were present before the beginning of the treatment and their rate of resistance-related genomic changes. This model is a valuable new tool when trying to understand the development of treatment resistance.
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Christina Curtis
Added on: 07-20-2021
[1] https://www.nature.com/articles/s41467-019-08593-4[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
