A multicellular 3D model of the human breast duct
2017
Queen Mary University of London, London, United Kingdom
The study describes the development of a 3D model to understand the interactions between myoepithelial and luminal cells in breast cancer. HER2-inducible human primary myoepithelial and luminal cells were combined in collagen gels and were able to recapitulate in vitro the physiological bilayer structures. Inducing the expression of HER2 led to robust luminal filling, recapitulating ductal carcinoma, that could be blocked by using the drug Trastuzumab. In summary, this model can recreate the interactions between myoepithelial and luminal cells in the early stages of breast cancer development, having the potential to be a powerful drug discovery platform.
A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer
Richard P Grose, Edward P Carter
Added on: 07-18-2021
[1] https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-017-0843-4[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
