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Hydrogel-based 3D breast cancer model

2016
Auburn University, Auburn, USA
#cancer cells, #hydrogel, #tissue engineering, #tumor microenvironment
To recapitulate the native tumor microenvironment, in this study a new poly-ethylene glycol-fibrinogen hydrogel is used to do 3D culture of three different human breast cancer cell lines. This new model improves cell viability, proliferation and 3D morphology and induces spatial heterogeneity within the hydrogels. Overall, this model shows the potential to be used in drug-testing applications.
PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture
Elizabeth A Lipke

Shantanu Pradhan et al. Journal of Biomedical Materials Research 2017 [1]   URL
EURL ECVAM [2]   URL
#657
Added on: 07-18-2021
[1] https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.35899[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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