Imaging-coupled 3D model to study tumor microenvironments
2016
University of Michigan Medical School, Ann Arbor, USA
The study presents a combination of an imaging device with a 3D model of quiescent breast cancer cells with bone marrow cells to perform drug testing. Through label-free methods, the researchers find that bone marrow stromal cells are capable of controlling the metabolism of co-cultured breast cancer cells. Therefore, the modulation of specific metabolic pathways can eliminate those quiescent breast cancer cells. Thus, confirming that this imaging-coupled spheroid model can be used to study tumor microenvironments.
Imaging sensitivity of quiescent cancer cells to metabolic perturbations in bone marrow spheroids
Gary D Luker
Added on: 07-14-2021
[1] https://www.mdpi.com/2379-139X/2/2/146[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
