Non Animal Testing Database

Imaging-coupled 3D model to study tumor microenvironments

University of Michigan Medical School, Ann Arbor, USA
The study presents a combination of an imaging device with a 3D model of quiescent breast cancer cells with bone marrow cells to perform drug testing. Through label-free methods, the researchers find that bone marrow stromal cells are capable of controlling the metabolism of co-cultured breast cancer cells. Therefore, the modulation of specific metabolic pathways can eliminate those quiescent breast cancer cells. Thus, confirming that this imaging-coupled spheroid model can be used to study tumor microenvironments.
Imaging sensitivity of quiescent cancer cells to metabolic perturbations in bone marrow spheroids
Gary D Luker
Added on: 07-14-2021
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!