Non Animal Testing Database

3D multicellular model combining endothelial and breast cancer spheroids

December 2016
Drexel University, Philadelphia, USA
A multicellular 3D model is developed by combining human endothelial spheroids and human breast cancer spheroids to mimic breast tumor interactions with vascular structures. The combination of both models is able to recreate a metastatic microenvironment that allows breast epithelial tumors to grow and migrate through the vascular-like structures, demonstrating the potential of this model to study the physiology of these cell-cell interactions and metastasis.
Vascular endothelial–breast epithelial cell coculture model created from 3D cell structures
Alisa Morss Clyne
Added on: 07-14-2021
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