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Microfluidic system to model cancer cell migration through blood vessels

2018
University of Cambridge, Cambridge, United Kingdom
#3D model, #cancer cells, #extracellular matrix, #metastasis, #microfluidic device, #real-time monitoring, #tissue engineering, #vascular system
To model cancer cell transendothelial migration, the researchers develop a microfluidic-chip system where they seed endothelial cells supported on extracellular matrix to mimic a microvessel environment. This system is coupled to live-cell imaging that can be used to study the migration dynamics in 3D. Thanks to this model, some key insights into the mechanisms of cancer cell migration are suggested, showing the potential of this model in cancer and microvascular research.
Image-assisted microvessel-on-a-chip platform for studying cancer cell transendothelial migration dynamics
Yan Yan Shery Huang

Cristina Bertulli et al. Scientific Reports 2018 [1]   URL
EURL ECVAM [2]   URL
#646
Added on: 07-14-2021
[1] https://www.nature.com/articles/s41598-018-30776-0[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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