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Biofabrication of 3D model to study bone marrow metastasis

October 2015
The George Washington University, Washington, USA
#3D model, #biofabrication, #breast cancer, #cancer cells, #hydrogel, #metastasis
The study presents the modelling of bone marrow metastatic invasion by breast cancer cells with a 3D-printed hydrogel matrix that mimics bone marrow microenvironment. The co-culture of human bone-marrow-derived mesenchymal stem cells and human breast cancer cells in this matrix is able to recapitulate morphological and migratory properties of breast cancer bone invasion. This shows that this model can be useful for other researcher to model metastasis.
3D printed nanocomposite matrix for the study of breast cancer bone metastasis
Lijie Grace Zhang

Wei Zhu et al. Nanomedicine: Nanotechnology, Biology and Medicine 2016 [1]   URL
EURL ECVAM [2]   URL
#643
Added on: 07-12-2021
[1] https://www.sciencedirect.com/science/article/abs/pii/S1549963415001884?via%3Dihub[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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